Karen Ann Isaac went home to Jesus on May 10, 2021 at age 64. Karen battled complications from a stroke in 2017, but that never stopped her from living life with a smile. She was born October 22, 1956 in Henderson, TX. Karen is survived by her husband of 45 years, Kenneth Isaac of Tatum, TX.; her brother, Robert and Loretta Boatwright of Tatum, TX.; her 3 children, Jaime and Domingo Russell of Gladewater, TX., Keith and Laura Isaac of Tyler, TX., and Casey and Amanda Isaac of Tatum, TX.; her 6 grandchildren, Brittney Isaac and Jodi Isaac of Tyler, TX.; Caiden Strickhausen of Kilgore, TX., Casey Isaac Jr and Devon Isaac of Tatum, TX., and Miya Russell of Gladewater, TX.; further survived by many nieces, nephews and other family and friends. Karen is preceded by her parents, Edward Lee and Annabell Boatwright and her grandparents, Robert and Nora Kuykendall. She will be remembered as a strong fighter, feisty, funny and selfless with a heart of gold. The Memorial Service will be at Grace Baptist Church at 119 Peavine Rd, Kilgore, Texas at 4:00 pm.